We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Angiogenic Potency of Amadori-Glycated Phosphatidylethanolamine.
- Authors
NAKAGAWA, KIYOTAKA; OAK, JEONG‐HO; MIYAZAWA, TERUO
- Abstract
Glycation has been thought to participate in diabetic vascular diseases. However, there are no reports about the effects of lipid glycation on endothelial dysfunction. In this study, we have evaluated whether Amadoriglycated phosphatidylethanolamine (Amadori-PE), a lipid-linked glycation compound, affected proliferation, migration, and tube formation of cultured human umbilical vein endothelial cells. These three factors involved in angiogenesis were significantly stimulated by Amadori-PE at a low concentration of less than 5 μM. Furthermore, Amadori-PE also stimulated the secretion of matrix metalloproteinase-2 (MMP-2), a pivotal enzyme in the initial step of angiogenesis. Our results indicated for the first time that Amadori-PE would elicit vascular disease through angiogenic potency on endothelial cells, thereby playing an active part in the development and progression of diabetic microangiopathy.
- Subjects
VASCULAR diseases; NEOVASCULARIZATION; PHOSPHATIDYLSERINES; DIABETIC angiopathies; LECITHIN; BIOLOGICAL transport
- Publication
Annals of the New York Academy of Sciences, 2005, Vol 1043, Issue 1, p413
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1333.048