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- Title
A Novel Antioxidant-Inhibited Dexamethasone-Mediated and Caspase-3--Independent Muscle Cell Death.
- Authors
ORZECHOWSKI, ARKADIUSZ; JANK, MICHAL; GAJKOWSKA, BARBARA; SADKOWSKI, TOMASZ; GODLEWSKIA, MICHAL MAREK
- Abstract
Dexamethasone (Dex)-mediated cell death is associated with repression of survival factors (AP-1, c-myc, NF-κB). Dex suppressed the activity of genes encoding antioxidant enzymes leading to impaired viability and apoptotic cell death. These findings suggest that reactive oxygen species inhibit protein synthesis and amplify m-calpain-dependent proteolysis. The events that led to death of L6 muscle cells were most likely triggered by Dex-mediated repression of antioxidative defenses on the genomic level.
- Subjects
APOPTOSIS; MUSCLE cells; GENES; CELL death; PROTEINS; ENZYMES; REACTIVE oxygen species; PROTEIN synthesis; CELLS
- Publication
Annals of the New York Academy of Sciences, 2004, Vol 1010, Issue 1, p205
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1299.035