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- Title
Sirolimus therapy may cause cardiac tamponade.
- Authors
Bertrand, Dominique; Desbuissons, Geoffroy; Pallet, Nicolas; Debure, Alain; Sartorius, Albane; Anglicheau, Dany; Mamzer, Marie-France; Legendre, Christophe; Sberro-Soussan, Rebecca
- Abstract
The side-effects associated with the immunosuppressive drug sirolimus are numerous and constitute a major limitation for its use in renal transplantation. In this study, we describe two cases of renal transplant recipients treated with sirolimus who developed pericardial tamponade associated with interstitial pneumonia, proteinuria, microcytic anemia and, in one case, lymphocytic meningitidis. An extensive search for infectious agents was negative, and all symptoms disappeared after sirolimus interruption. Therefore, this case demonstrates for the first time that sirolimus can cause pericardial tamponade as well as lymphocytic meningitidis.
- Subjects
RAPAMYCIN; CARDIAC tamponade; IMMUNOSUPPRESSIVE agents; KIDNEY diseases; PULMONARY fibrosis; PROTEINURIA
- Publication
Transplant International, 2013, Vol 26, Issue 2, pe4
- ISSN
0934-0874
- Publication type
Article
- DOI
10.1111/tri.12025