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- Title
Highly N<sup>2</sup>-Selective Coupling of 1,2,3-Triazoles with Indole and Pyrrole.
- Authors
Wen, Jian; Zhu, Li‐Li; Bi, Qing‐Wei; Shen, Zhu‐Qing; Li, Xiao‐Xiao; Li, Xin; Wang, Zhen; Chen, Zili
- Abstract
Hydrogen-bond mediated coupling of 1,2,3-triazoles to indoles and pyrroles results in N2 selective functionalization of the triazole moiety in moderate to excellent yields. The reaction was tolerant of un-, mono- and disubstituted triazoles and was applied to synthesize tryptophan derived fluorescent amino acids.
- Subjects
HYDROGEN bonding; TRIAZOLES; INDOLE compounds; PYRROLES; FUNCTIONAL groups; TRYPTOPHAN; AMINO acids; FLUORESCENT proteins
- Publication
Chemistry - A European Journal, 2014, Vol 20, Issue 4, p974
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201302761