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- Title
2D Zn‐Porphyrin‐Based Co(II)‐MOF with 2‐Methylimidazole Sitting Axially on the Paddle–Wheel Units: An Efficient Electrochemiluminescence Bioassay for SARS‐CoV‐2.
- Authors
Li, Yi‐Xuan; Li, Jing; Zhu, Dunru; Wang, Ju‐Zheng; Shu, Guo‐Fang; Li, Junji; Zhang, Sheng‐Li; Zhang, Xue‐Ji; Cosnier, Serge; Zeng, Hai‐Bo; Shan, Dan
- Abstract
High electrocatalytic activity with tunable luminescence is crucial for the development of electrochemiluminescence (ECL) luminophores. In this study, a porphyrin‐based heterobimetallic 2D metal organic framework (MOF), [(ZnTCPP)Co2(MeIm)] (1), is successfully self‐assembled from the zinc(II) tetrakis(4‐carboxyphenyl)porphine (ZnTCPP) linker and cobalt(II) ions in the presence of 2‐methylimidazole (MeIm) by a facile one‐pot reaction in methanol at room temperature. On the basis of the experimental results and the theoretical calculations, the MOF 1 contains paddle–wheel [Co2(‐CO2)4] secondary building units (SBUs) axially coordinated by a MeIm ligand, which is very beneficial to the electron transfer between the Co(II) ions and oxygen. Combining the photosensitizers ZnTCPP and the electroactive [Co2(‐CO2)4] SBUs, the 2D MOF 1 possesses an excellent ECL performance, and can be used as a novel ECL probe for rapid nonamplified detection of the RdRp gene of SARS‐CoV‐2 with an extremely low limit of detection (≈30 aM).
- Subjects
ELECTROCHEMILUMINESCENCE; ZINC porphyrins; METAL-organic frameworks; BIOLOGICAL assay; SARS-CoV-2; LUMINOPHORES
- Publication
Advanced Functional Materials, 2022, Vol 32, Issue 48, p1
- ISSN
1616-301X
- Publication type
Article
- DOI
10.1002/adfm.202209743