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- Title
Photocytotoxicity and G-quadruplex DNA interaction of water-soluble gallium(III) tris( N-methyl-4-pyridyl)corrole complex.
- Authors
Zhang, Zhao; Wen, Jin ‐ Yan; Lv, Biao ‐ Biao; Li, Xu; Ying, Xiao; Wang, Ya ‐ Jun; Zhang, Hai ‐ Tao; Wang, Hui; Liu, Hai ‐ Yang; Chang, C. ‐ K.
- Abstract
A water-soluble cationic gallium corrole, 5,10,15-tris( N-methyl-4-pyridyl)corrolatogallium(III) ( 3), was prepared and characterized. The photocytotoxicity of 3 was investigated using Hep G2 cancer cell line. Upon treatment with corrole 3 and irradiation, of tumor cell nuclei was observed, which led to apoptosis. Flow cytometric analysis clearly showed the efficient induction of apoptotic cell death, and corrole 3 exhibited high photocytotoxicity towards Hep G2 cancer cells (IC50 = 60 nM). Furthermore, the binding behavior of corrole 3 with c-MYC G-quadruplex DNA, a potent target for antitumor drugs, was investigated using spectroscopic methods and molecular docking simulation. Copyright © 2015 John Wiley & Sons, Ltd.
- Subjects
CELL-mediated cytotoxicity; PHOTOCHEMISTRY; QUADRUPLEX nucleic acids; GALLIUM; METAL complexes; SOLUBILITY
- Publication
Applied Organometallic Chemistry, 2016, Vol 30, Issue 3, p132
- ISSN
0268-2605
- Publication type
Article
- DOI
10.1002/aoc.3408