We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The influence of triphenylantimony(V) catecholate and its spiroendoperoxide on lipid peroxidation.
- Authors
Smolyaninov, Ivan V.; Antonova, Natalia A.; Poddel'sky, Andrey I.; Smolyaninova, Susanna A.; Osipova, Viktoria P.; Luzhnova, Svetlana A.; Berberova, Nadezhda T.; Pimenov, Yuri T.
- Abstract
The effects of triphenylantimony(V) catecholate Ph3Sb(Cat) (1) and its spiroendoperoxide Ph3Sb(L-O2) (2) (Cat = 3,6-di- tert-butyl-4,5-dimethoxycatecholate) on lipid peroxidation (LP) in vitro and in vivo were examined in BALB/c line mice. A comparative study of the impact of compounds 1 and 2 on LP under similar conditions was made by measuring the formation of thiobarbituric acid reactive substances (TBARS). The anti- or pro-oxidant action of complexes 1 and 2 may be caused by the different redox level of the ligand acting as radical scavenger and/or by the bound molecular oxygen promoting the oxidation process. Biological experiments ( in vitro and in vivo) were performed using mouse tissue homogenates. Decreasing TBARS concentration was observed in all examined tissues and blood serum ( in vitro as well as in vivo) for catecholate 1. These results indicate inhibition of LP in the presence of complex 1. In contrast to 1, spiroendoperoxide 2 increases the level of TBARS in tissue homogenates. Minor fluctuations of TBARS concentration in erythrocytes and in blood serum indicate the absence of an obvious anti/pro-oxidant influence of 2 on the LP process in vivo. The role of catecholate fragment was found to be essential in explaining antioxidant properties. Copyright © 2014 John Wiley & Sons, Ltd.
- Subjects
ORGANOANTIMONY compounds; LIPID peroxidation (Biology); LIGANDS (Chemistry); OXIDATION; SERUM
- Publication
Applied Organometallic Chemistry, 2014, Vol 28, Issue 4, p274
- ISSN
0268-2605
- Publication type
Article
- DOI
10.1002/aoc.3120