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- Title
Delayed gadolinium-enhanced MRI of cartilage in the ankle at 3 T: Feasibility and preliminary results after matrix-associated autologous chondrocyte implantation.
- Authors
Domayer, Stephan E.; Trattnig, Siegfried; Stelzeneder, David; Hirschfeld, Clemens; Quirbach, Sebastian; Dorotka, Ronald; Nehrer, Stefan; Pinker, Katja; Chan, Jenny; Mamisch, Tallal Charles; Dominkus, Martin; Welsch, Götz H.
- Abstract
Purpose: To demonstrate the feasibility of delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) in the ankle at 3 T and to obtain preliminary data on matrix associated autologous chondrocyte (MACI) repair tissue. Materials and Methods: A 3D dual flip angle sequence was used with an eight-channel multipurpose coil at 3 T to obtain T1 maps both pre- and postintravenous contrast agent (Magnevist, 0.2 mM/kg). Postcontrast T1 over time was evaluated in three volunteers; a modified dGEMRIC protocol was then used to assess 10 cases after MACI in the ankle. Results: Forty-five minutes were found sufficient for maximum T1 decrease. MACI cases had a precontrast mean T1 of 1050 ± 148.4 msec in reference cartilage (RC) and 1080 ± 165.6 msec in repair tissue (RT). Postcontrast T1 decreased to 590 ± 134.0 msec in RC and 554 ± 133.0 msec in RT. There was no significant difference between the delta relaxation rates in RT (9.44 × 10−4 s−1) and RC (8.04 × 10−4 s−1, P = 0.487). The mean relative delta relaxation rate was 1.34 ± 0.83. Conclusion: It is feasible to assess the thin cartilage layers of the ankle with dGEMRIC at 3 T; MACI can yield RT with properties similar to articular cartilage. J. Magn. Reson. Imaging 2010;31:732-739. © 2010 Wiley-Liss, Inc.
- Publication
Journal of Magnetic Resonance Imaging, 2010, Vol 31, Issue 3, p732
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.22093