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- Title
Lack of association between Poly(ADP-ribose) polymerase (PARP) polymorphisms and rheumatoid arthritis in a Korean population.
- Authors
Lee, Kyeong-A; Bang, So-Young; Park, Byung; Kim, Jeong-Hyun; Shin, Hyoung; Bae, Sang-Cheol
- Abstract
Several studies have investigated the roles of genetic polymorphisms in rheumatoid arthritis (RA). Some of these studies reported that polymorphisms of poly(ADP-ribose) polymerase 1 gene ( PARP- 1) are linked to rheumatoid arthritis. Poly(ADP-ribose) polymerase is an enzyme involved in DNA repair, genomic stability, apoptosis, gene transcription, proliferation, and autoimmunity. To determine whether genetic polymorphisms of PARP- 1 are related to rheumatoid arthritis in a Korean population, six single nucleotide polymorphisms (SNPs), which were selected based on LDs and minor allele frequency (MAF > 0.05) in our previous study, were genotyped in 1,202 patients with rheumatoid arthritis and 979 unrelated healthy controls. As a result, no significant association between the susceptibility to rheumatoid arthritis and PAPR- 1 polymorphisms was found. However, in further analysis depending on the radiological severity of rheumatoid arthritis, one PARP- 1 polymorphism, rs1805413 (OR = 0.11; 95% CI = 0.02-0.55; P = 0.007; P = 0.04), and one haplotype ( ht6, OR = 0.11; 95% CI = 0.02-0.55; P = 0.007; P = 0.04) were significantly associated with the radiological severity risk of RA in a recessive model. In addition, a recessive model revealed a correlation between one RA haplotype ( ht4) and anti-CCP antibody negativity (OR 0.24, 95% CI 0.10-0.63, P = 0.003; P = 0.02). Despite a possible association between PARP- 1 and the radiological severity of RA, this study found no statistical association between PARP- 1 polymorphisms and the susceptibility to rheumatoid arthritis in a Korean population.
- Subjects
RHEUMATOID arthritis; GENETIC polymorphisms; AUTOIMMUNE diseases; RHEUMATISM; POPULATION genetics
- Publication
Rheumatology International, 2012, Vol 32, Issue 1, p91
- ISSN
0172-8172
- Publication type
Article
- DOI
10.1007/s00296-010-1589-9