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- Title
An Overview of Saturated Cyclic Ethers: Biological Profiles and Synthetic Strategies.
- Authors
Lu, Qili; Harmalkar, Dipesh S.; Choi, Yongseok; Lee, Kyeong
- Abstract
Saturated oxygen heterocycles are widely found in a broad array of natural products and other biologically active molecules. In medicinal chemistry, small and medium rings are also important synthetic intermediates since they can undergo ring-opening and -expansion reactions. These applications have driven numerous studies on the synthesis of oxygen-containing heterocycles and considerable effort has been devoted toward the development of methods for the construction of saturated oxygen heterocycles. This paper provides an overview of the biological roles and synthetic strategies of saturated cyclic ethers, covering some of the most studied and newly discovered related natural products in recent years. This paper also reports several promising and newly developed synthetic methods, emphasizing 3–7 membered rings.
- Subjects
CYCLIC ethers; RING-opening reactions; NATURAL products; PHARMACEUTICAL chemistry; HETEROCYCLIC compounds
- Publication
Molecules, 2019, Vol 24, Issue 20, p3778
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24203778