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- Title
Gastroprotective Activity of Parastrephia quadrangularis (Meyen), Cabrera from the Atacama Desert.
- Authors
Ardiles, Alejandro; Barrientos, Ruth; Simirgiotis, Mario J.; Bórquez, Jorge; Sepúlveda, Beatriz; Areche, Carlos
- Abstract
Forty-three metabolites including several methoxylated flavonoids, tremetones, and ent-clerodane diterpenes were accurately identified for the first time in the ethanolic extract of P. quadrangularis by means of hyphenated UHPLC-quadrupole Orbitrap mass spectrometry, and seven isolated compounds were tested regarding gastroprotective activity using the HCl/EtOH-induced lesion model in mice. A new tremetone (compound 6) is reported based on spectroscopic evidence. The isolated clerodanes and tremetones showed gastroprotective activity in a mouse model, evidenced by compound 7 (p-coumaroyloxytremetone), which showed the highest gastroprotective activity (76%), which was higher than the control drug lansoprazole (72%). Our findings revealed that several constituents of this plant have gastroprotective activity, and particularly, p-coumaroyloxytremetone could be considered as a lead molecule to explore new gastroprotective agents. This plant is a rich source of biologically active tremetones and terpenoids which can support the ethnobotanical use of the plant.
- Subjects
FLAVONOIDS; MASS spectrometry; QUADRUPOLE splitting; QUADRUPOLE moments; CLERODANES
- Publication
Molecules, 2018, Vol 23, Issue 9, p2361
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules23092361