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- Title
Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis.
- Authors
Escarcena, Ricardo; Perez-Meseguer, Jonathan; Olmo, Esther del; Alanis-Garza, Blanca; Garza-González, Elvira; Salazar-Aranda, Ricardo; De Torres, Noemí Waksman
- Abstract
Seventeen new derivatives of the natural diterpene leubethanol, including some potential pro-drugs, with changes in the functionality of the aliphatic chain or modifications of aromatic ring and the phenolic group, were synthesized and tested in vitro by the MABA technique for their activity against the H37Rv strain of Mycobacterium tuberculosis. Some compounds showed antimycobacterial selectivity indices higher than leubethanol.
- Subjects
DITERPENES synthesis; MYCOBACTERIUM tuberculosis; ALIPHATIC compounds; AROMATIC compounds; PHENOLS; ETHANOL
- Publication
Molecules, 2015, Vol 20, Issue 4, p7245
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules20047245