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- Title
First trimester TTR-RBP4-ROH complex and angiogenic factors in the prediction of small for gestational age infant's outcome.
- Authors
Fruscalzo, Arrigo; Frommer, Julia; Londero, Ambrogio; Henze, Andrea; Schweigert, Florian; Nofer, Jerzy-Roch; Steinhard, Johannes; Klockenbusch, Walter; Schmitz, Ralf; Raila, Jens; Londero, Ambrogio P; Schweigert, Florian J
- Abstract
<bold>Purpose: </bold>To study the role of the TTR-RBP4-ROH complex components (transthyretin, serum retinol binding protein, retinol) and of angiogenic factors PlGF (placental growth factor) and sFlt-1 (soluble fms-like tyrosine kinase-1) in pregnancies complicated by small for gestational age infants (SGA).<bold>Methods: </bold>Case control study conducted on maternal serum collected between 11 + 0 to 13 + 6 weeks of gestation. TTR, RBP4, ROH, PlGF and sFlt-1 were measured in SGA patients (birth weight <10%) who delivered at term (n = 37) and before 37 weeks of gestation (n = 17) and in a matched control group with uneventful pregnancies (n = 37).<bold>Results: </bold>We found decreased RBP4 in SGA patients that delivered fetuses <3% and in fetuses delivered after the 37 weeks of gestation compared to controls [1.50 (95% CI 1.40-1.75) vs 1.62 (95% CI 1.47-1.98), p < 0.05]. Further, we found lower PlGF and sFlt-1 concentrations in SGA that delivered before 37 weeks of gestation compared to controls (respectively, PIGF and sFlt-1: 39.7 pg/ml (95% CI 32.3-66.3) vs 62.9 pg/ml (95% CI 45.2-78.4) and 906 pg/ml (95% CI 727-1626) vs 1610 pg/ml (95% CI 1088-212), p < 0.05).<bold>Conclusions: </bold>First trimester maternal serum RBP4 and angiogenic factors PlGF and sFlt-1 can differently predict the timing of delivery of pregnancies complicated by SGA fetuses.
- Subjects
FIRST trimester of pregnancy; TRANSTHYRETIN; RETINOL-binding proteins; PLACENTAL growth factor; PROTEIN-tyrosine kinases; BIRTH size; BIRTH weight; CARRIER proteins; CELL receptors; GESTATIONAL age; PREECLAMPSIA; QUESTIONNAIRES; SERUM albumin; VITAMIN A; CASE-control method; BLOOD
- Publication
Archives of Gynecology & Obstetrics, 2017, Vol 295, Issue 5, p1157
- ISSN
0932-0067
- Publication type
journal article
- DOI
10.1007/s00404-017-4338-4