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- Title
Cell Death and Development of Fibrotic Alterations in Lung Granuloma of BALB/c Mice during Chronic BCG-Induced Granulomatosis.
- Authors
Cherdantseva, L. A.; Potapova, O. V.; Sharkova, T. V.; Anikina, A. M.; Kovner, A. V.; Troitskii, A. V.; Shkurupy, V. A.
- Abstract
Light microscopy, immunohistochemistry, and morphometric examinations established that cell death in lung granulomas of BCG-infected mice resulted mainly from activation of receptor-mediated apoptosis, which did not prevent the persistence of the causative agent in macrophages of the granulomas and promoted the formation of pronounced fibrosis in granulomas and pulmonary interstitium.
- Subjects
CELL death; APOPTOSIS; BCG vaccines; GRANULOMA; INFLAMMATION; NECROSIS
- Publication
Bulletin of Experimental Biology & Medicine, 2018, Vol 165, Issue 1, p48
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-018-4096-8