We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Biological Activity of Spirocyclic Hydroxamic Acids.
- Authors
Neganova, M.; Mishchenko, D.; Serkova, T.; Vystorop, I.; Shevtsova, E.
- Abstract
Iron-chelating activity of synthesized spirocyclic hydroxamic acids, their toxicity, and effects on mitochondrial function were studied using primary culture of cerebral cortical neurons from newborn rats. All tested compounds effectively chelated Fe(II) ions. Activity of spirocyclic hydroxamic acids more strictly depended on the structure their piperidine, but not imidazolidine fragment. All compounds were non-toxic for normal neuronal culture.
- Subjects
HYDROXAMIC acids; MITOCHONDRIA; CEREBRAL cortex; NEURONS; PIPERIDINE; IRON chelates
- Publication
Bulletin of Experimental Biology & Medicine, 2016, Vol 162, Issue 2, p228
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-016-3582-0