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- Title
A cross-coupling synthesis of functionalised biaryls using Knochel-type organozinc reagents and a pyridine enhanced palladium catalyst.
- Authors
Wang, Min; Liu, Fang; Zeng, Meng-Tian; Xu, Wan; Liu, Min; Dong, Zhi-Bing
- Abstract
A variety of functionalised biaryls were synthesised on the 20-30 mmol scale by using Knochel type organozinc reagents (organozinc reagents prepared from aryl halides, Zn powder and LiCl) catalysed by PEPPSI (a pyridine enhanced palladium catalyst). The protocol enabled the Negishi reactions to proceed in a smooth, rapid and mild way to give the corresponding products in excellent yields (80 ∼ 96%). Sensitive functional groups, such as CN and COOEt groups, were tolerated in the coupling reaction.
- Subjects
PYRIDINE; 2-Mercaptopyridine; HETEROCYCLIC compounds; 1-Methylimidazole; CATALYSTS; CATALYST supports
- Publication
Journal of Chemical Research, 2016, Vol 40, Issue 6, p382
- ISSN
1747-5198
- Publication type
Article
- DOI
10.3184/174751916X14636735575269