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- Title
Synthesis of novel indolizine, pyrrolo[1,2-a] quinoline, and 4,5-dihydrothiophene derivatives via nitrogen ylides and their antimicrobial evaluation.
- Authors
Gomha, Sobhi M.; Dawood, Kamal M.
- Abstract
Treatment of 2-(2-bromoacetyl)-3H-benzo[f]chromen-3-one with pyridine, quinoline, and 2-methylquinoline afforded the corresponding pyridinium, quinolinium and 2-methylquinolinium bromides. The latter salts underwent [3 + 2] 1,3-dipolar cycloaddition with some electron deficient acetylene and ethylene derivatives to give the corresponding indolizine and pyrrolo[1,2-a]quinoline derivatives. Moreover, 2-(2-bromoacetyl)-3H-benzo[f]chromen-3-one reacted with arylidene cyanothioacetamides to afford the corresponding 2-amino-4,5-dihydrothiophene-3-carbonitriles. The synthesised compounds were characterised based on their elemental analysis and spectral data. Antimicrobial activity of some of the synthesised compounds was evaluated.
- Subjects
PQQ (Biochemistry); NITROGEN ylides; ANTI-infective agents; RING formation (Chemistry); ANTINEOPLASTIC agents
- Publication
Journal of Chemical Research, 2014, Vol 38, Issue 9, p515
- ISSN
1747-5198
- Publication type
Article
- DOI
10.3184/174751914X14067338307126