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- Title
Variability patterns in dual antiplatelet therapy following endovascular repair of intracranial aneurysms: Insight into regimen heterogeneity and the need for a consensus.
- Authors
Wadhwa, Aryan; Mensah, Emmanuel; Young, Michael; Ogilvy, Christopher S.
- Abstract
This comprehensive review delves into the evolving field of neurointervention for intracranial aneurysms, exploring the critical adjunct of Dual Antiplatelet Therapy (DAPT) to endovascular coiling, stent-assisted coiling (SAC), flow-diversion stents, and flow-disruption (intrasaccular) devices. Despite growing evidence supporting the success of DAPT in reducing thromboembolic events, the lack of consensus on optimal regimens, doses, and duration is evident. Factors contributing to this variability include genetic polymorphisms affecting treatment response and ongoing debates regarding the clinical significance of hemorrhagic complications associated with DAPT. This review analyzes pre- and post-procedural antiplatelet usage across various interventions. The imperative lies in ongoing research to define optimal DAPT durations, ensuring a nuanced approach to the delicate balance between thrombosis and hemorrhage in intracranial aneurysm management.
- Subjects
ENDOVASCULAR aneurysm repair; PLATELET aggregation inhibitors; INTRACRANIAL aneurysms; INTRACRANIAL hemorrhage; GENETIC polymorphisms; URINARY diversion
- Publication
Acta Neurochirurgica, 2024, Vol 166, Issue 1, p1
- ISSN
0001-6268
- Publication type
Article
- DOI
10.1007/s00701-024-06137-4