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- Title
Serum levels of claudin- 5 and Apelin-13 in patients with depression and their relationship with disease progression and sleep disorders.
- Authors
DING Zhiqiang; DONG Qiangli; LIANG Ying; SHI Wenyuan.
- Abstract
Objective To investigate the changes in serum levels of claudin-5 and Apelin-13 in patients with depression and their relationship with disease progression and sleep disorders. Methods A total of 128 patients with depression admitted to our hospital from June 2021 to July 2023 were selected as the study group, and another 128 patients who underwent physical examinations during the same period were selected as the control group. The correlation between the expression levels of serum claudin-5 and Apelin-13 in patients with depression and the Hamilton Depression Rating Scale (HAMD) score, as well as the diagnostic value of serum claudin-5 and Apelin- 13 for the severity of depression in patients were analyzed. Results The expression level of claudin-5 in the serum of patients in study group was higher than that of the control group, which increased with the severity of the disease (P < 0.05) and was positively correlated with the HAMD score (r = 0.713, P < 0.05). In addition, the expression level of claudin-5 in the serum of patients with sleep disorders was higher than that of those without sleep disorders (P < 0.05), and the trend of changes in the expression level of Apelin-13 was opposite, Age, age at onset of depression, and claudin-5 were factors for sleep disorders in patients with depression, while Apelin-13 was a protective factor (P < 0.05), The combined detection of serum claudin-5 and Apelin-13 is superior to their individual detection(Z combined detection - claudin-5 = 2.393, Z combined detection - Apelin-13 = 1.964, P = 0.016, 0.044). Conclusion The expression levels of claudin-5 and Apelin-13 in serum of patients with depression were related to the progression of disease and the sleep disorders and the combined detection has high diagnostic value for severe depression.
- Subjects
SLEEP disorders; MENTAL depression; HAMILTON Depression Inventory; DISEASE progression
- Publication
Journal of Practical Medicine / Shiyong Yixue Zazhi, 2024, Vol 40, Issue 12, p1677
- ISSN
1006-5725
- Publication type
Article
- DOI
10.3969/j.issn.1006-5725.2024.12.011