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- Title
Potentiation of Hemostimulating Effects of Erythropoietin with Pegylated Hyaluronate-Endo-β-N-Acetylhexosaminidase.
- Authors
Dygai, A.; Zyuz'kov, G.; Zhdanov, V.; Udut, E.; Gurto, R.; Miroshnichenko, L.; Simanina, E.; Khrichkova, T.; Stavrova, L.; Chaikovsky, A.; Artamonov, A.; Bekarev, A.; Madonov, P.; Minakova, M.; Markova, T.
- Abstract
Pegylated hyaluronate-endo-β-N-acetylhexosaminidase considerably potentiates the hemostimulating effects of erythropoietin due to intensifi cation of proliferation and differentiation of erythroid precursors against the background of enhanced secretion of hemopoietins by nonadherent hemopoiesis-inducing environment cells and elevation of serum erythropoietin concentration. The use of the enzyme allows 10-fold reduction of the maximum effective erythropoietin dose.
- Subjects
ERYTHROPOIETIN; HEMATOPOIESIS; EXPERIMENTAL pharmacology; EXPERIMENTAL toxicology; EXPERIMENTAL medicine
- Publication
Bulletin of Experimental Biology & Medicine, 2012, Vol 153, Issue 5, p684
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-012-1799-0