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- Title
Making a firm decision: multifaceted regulation of cell fate in the early mouse embryo.
- Authors
Zernicka-Goetz, Magdalena; Morris, Samantha A.; Bruce, Alexander W.
- Abstract
The preimplantation mammalian embryo offers a striking opportunity to address the question of how and why apparently identical cells take on separate fates. Two cell fate decisions are taken before the embryo implants; these decisions set apart a group of pluripotent cells, progenitors for the future body, from the distinct extraembryonic lineages of trophectoderm and primitive endoderm. New molecular, cellular and developmental insights reveal the interplay of transcriptional regulation, epigenetic modifications, cell position and cell polarity in these two fate decisions in the mouse. We discuss how mechanisms proposed in previously distinct models might work in concert to progressively reinforce cell fate decisions through feedback loops.
- Subjects
MAMMAL remains (Archaeology); DECISION making; EMBRYOS; CELL determination; DEVELOPMENTAL cytology; RNA physiology; EMBRYONIC physiology; CELL differentiation; BLASTOCYST; GENES; MICE; STEM cells; PHYSIOLOGY
- Publication
Nature Reviews Genetics, 2009, Vol 10, Issue 7, p467
- ISSN
1471-0056
- Publication type
journal article
- DOI
10.1038/nrg2564