We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Family-based designs in the age of large-scale gene-association studies.
- Authors
Laird, Nan M.; Lange, Christoph
- Abstract
Both population-based and family-based designs are commonly used in genetic association studies to locate genes that underlie complex diseases. The simplest version of the family-based design — the transmission disequilibrium test — is well known, but the numerous extensions that broaden its scope and power are less widely appreciated. Family-based designs have unique advantages over population-based designs, as they are robust against population admixture and stratification, allow both linkage and association to be tested for and offer a solution to the problem of model building. Furthermore, the fact that family-based designs contain both within- and between-family information has substantial benefits in terms of multiple-hypothesis testing, especially in the context of whole-genome association studies.
- Subjects
GENES; FAMILIAL diseases; GENETIC disorders; DISEASES; GENOMES
- Publication
Nature Reviews Genetics, 2006, Vol 7, Issue 5, p385
- ISSN
1471-0056
- Publication type
Article
- DOI
10.1038/nrg1839