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- Title
Mesenchymal/stromal stem cells: necessary factors in tumour progression.
- Authors
Li, Xinyu; Fan, Qing; Peng, Xueqiang; Yang, Shuo; Wei, Shibo; Liu, Jingang; Yang, Liang; Li, Hangyu
- Abstract
Mesenchymal/stromal stem cells (MSCs) are a crucial component of the tumour microenvironment (TME). They can be recruited from normal tissues into the TME and educated by tumour cells to transform into tumour-associated MSCs, which are oncogenic cells that promote tumour development and progression by impacting or transforming into various kinds of cells, such as immune cells and endothelial cells. Targeting MSCs in the TME is a novel strategy to prevent malignant processes. Exosomes, as communicators, carry various RNAs and proteins and thus link MSCs and the TME, which provides options for improving outcomes and developing targeted treatment.
- Subjects
STEM cell factor; STROMAL cells; STEM cells; ENDOTHELIAL cells; TUMOR microenvironment; MESENCHYMAL stem cells; EXOSOMES
- Publication
Cell Death Discovery, 2022, Vol 8, Issue 1, p1
- ISSN
2058-7716
- Publication type
Article
- DOI
10.1038/s41420-022-01107-0