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- Title
Evaluation of blocking mechanisms against immunological responses in patients with laryngeal carcinoma.
- Authors
Morra, B.; Beatrice, F.; Cavallo, G. P.; Bussi, M.; Di Fortunato, V.; Poggio, E.; Vercillino, M.; Sartoris, A.; Cortesina, G.; Vercellino, M
- Abstract
The specific tumor-induced leukocyte inhibition factor (LIF) production in laryngeal cancer patients has been investigated before and after the removal of adherent cells in order to evaluate the existence of a suppressor activity; 20 patients served as subject. The LIF production, after challenging the lymphocytes with 3MKC1 autologous tumor extracts, was significant in 12 patients and showed a further significant increase after the removal of adherent cells. In 3 patients with no previous significant LIF production, there was a conversion to significance when the adherent cells were removed. The other patients did not show any significant variation. These data seem to suggest the existence of a suppressor activity exerted by adherent cells in laryngeal cancer patients on LIF production.
- Publication
Laryngoscope, 1984, Vol 94, Issue 6, p825
- ISSN
0023-852X
- Publication type
journal article
- DOI
10.1288/00005537-198406000-00019