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- Title
The Effects of Dizocilpine and Phencyclidine on Prepulse Inhibition of the Acoustic Startle Reflex and on Prepulse-Elicited Reactivity in C57BL6 Mice.
- Authors
Yee, Benjamin K.; Chang, D.L. Tilly; Feldon, Joram
- Abstract
Prepulse inhibition (PPI) of the acoustic startle response refers to the reduction in startle reaction to a startle-eliciting stimulus when it is shortly preceded by a subthreshold pre pulse stimulus. Here, we evaluated the possible effects on prepulse-elicited reactivity by dizocilpine (MK-801) and phencyclidine (PCP) in the PPI of acoustic startle paradigm in C57BL6/J mice. The aim was to ascertain whether these two drugs would affect prepulse-elicited reactivity in a manner similar to apomorphine, which enhances prepulse-elicited reactivity at doses that disrupt FRI. In two dose-response studies, we showed that both drugs exhibited a tendency to attenuate prepulse-elicited reaction at higher doses when FRI was severely disrupted. On the other hand, at lower doses when FRI was marginally disrupted, reaction to the prepulse, if anything, tended to increase. It is concluded that FRI disruption induced by noncompetitive NMDA receptor antagonists can be distinguished from apomorphine-induced FRI disruption by their concomitant effects on prepulse-elicited reactivity. Our data support the suggestion that dopamine receptor agonists and NMDA receptor antagonists disrupt FRI via interference with distinct neural pathways or neuronal systems.
- Subjects
STARTLE reaction; REFLEXES; NEUROPHYSIOLOGY; PHENCYCLIDINE; HALLUCINOGENIC drugs; PSYCHIATRIC drugs; SCHIZOPHRENIA; SENSORIMOTOR cortex
- Publication
Neuropsychopharmacology, 2004, Vol 29, Issue 10, p1865
- ISSN
0893-133X
- Publication type
Article
- DOI
10.1038/sj.npp.1300480