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- Title
Allelic Variation of Serotonin Transporter Function Modulates the Brain Electrical Response for Error Processing.
- Authors
Fallgatter, Andreas J.; Herrmann, Martin J.; Roemmier, Josefine; Ehlis, Ann-Christine; Wagener, Annika; Heidrich, Anke; Ortega, Gabriele; Yong Zeng; Lesch, Klaus-Peter
- Abstract
A functional length variation in the transcriptional control region of the serotonin transporter gene (5-HTTLPR) influences brain function, personality traits, and susceptibility to psychiatric disorders. Here we measured prefrontal brain function by means of event-related potentials during an error processing paradigm. Physiologically, occurrence of an error elicits two specific electrical responses in the prefrontal cortex, the early error related negativity (Ne/ERN) and the later occurring error positivity (Pe), reflecting different components of error processing. Healthy subjects with one or two copies of the Iow-activity 5-HTTLPR short variant showed significantly higher amplitudes of the Ne/ERN and a trend to higher amplitudes of the Pe as compared to age- and gender-matched individuals homozygous for the long allele. Performance measures and latencies of these ERP-components did not differ between groups. These results indicate that the 5-HTTLPR short variant is associated with enhanced responsiveness of the brain and further supports the notion that prefrontal brain function is influenced by allelic variation in serotonin transporter function.
- Subjects
SEROTONIN; TRYPTAMINE; NEUROTRANSMITTERS; BRAIN; PERSONALITY; NEUROPSYCHOPHARMACOLOGY
- Publication
Neuropsychopharmacology, 2004, Vol 29, Issue 8, p1506
- ISSN
0893-133X
- Publication type
Article
- DOI
10.1038/sj.npp.1300409