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- Title
Effect of feeding flax or linseed meal on progesterone clearance rate in ovariectomized ewes.
- Authors
Galbreath, C. W.; O'Neil, M. R.; Kirsch, J. D.; Schroeder, J. W.; Odde, K. G.; Lardy, G. P.; Vonnahme, K. A.
- Abstract
Evidence suggests feeding flax can increase fertility in dairy cows, and women who consume linseed meal (LSM) had a longer luteal phase during their menstrual cycle. We hypothesized that flax or LSM decreases the rate of progesterone (P4) metabolism in cyclic females. Our objective was to determine if flax or LSM decreases the clearance rate of P4 in ovariectomized ewes receiving a P4 releasing device (CIDR). Mature ewes (n = 21) were ovariectomized and fed a phytoestrogen (PE)-free diet based on beet pulp, for at least 30 d post-ovariectomy. Ewes were fed at maintenance based on metabolic body wt and were weighed every 2 wk throughout the feeding period. Thereafter, ewes were assigned randomly to control (PE-free; n = 7), flax (n = 7), or LSM (n = 7) diets. All diets were isocaloric and isonitrogenous. Body condition score (BCS; scale 1-5) was also measured at the onset and conclusion of the trial. On d 20 of feeding, a CIDR was inserted vaginally. Beginning on d 25, blood samples were obtained via jugular venipuncture. Samples were collected before CIDR removal (0 h) and at 0.5, 1, 2, 6, 12, and 24 h post-CIDR removal. Serum was assayed for P4. There was no difference in initial body wt (P = 0.97) or BCS (P = 0.47; 63.8 ± 1.7 kg or 3.3 ± 1.8, respectively) and no difference in final body wt (P = 0.89) or BCS (P = 0.56; 67.5 ± 1.9 kg or 3.4 ± 0.2, respectively). There was no time by diet interaction (P = 0.15) on P4 concentrations. From 0 to 24 h, P4 decreased (P < 0.01; 1.55 ± 0.09 to 0.27 ± 0.01 ng/ml). Ewes fed LSM had greater (P < 0.04) P4 across all sampling times compared to control- and flax-fed ewes (LSM = 0.65 ± 0.08; control = 0.57 ± 0.06; flax = 0.56 ± 0.05). Progesterone at 0 h was greater (P < 0.05) in LSM-fed ewes (1.82 ± 0.20 ng/ml) compared to flax- (1.39 ± 0.07 ng/ml) and control-fed (1.45 ± 0.13 ng/ml) ewes. Although clearance rates did not differ, LSM-fed ewes appeared to absorb a greater level of P4 from the CIDR. Feeding LSM to cyclic females may increase circulating P4 aiding in maintenance of pregnancy. Further investigation is warranted to determine the mechanism by which LSM influences P4 concentrations
- Subjects
BOARD of Governors of the Federal Reserve System (U.S.); EWES; FLAX; PROGESTERONE; FLAXSEED; LUTEAL phase; MENSTRUAL cycle; BEETS; ESTRUS
- Publication
Journal of Animal Science, 2006, Vol 84, p433
- ISSN
0021-8812
- Publication type
Article