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- Title
Severe Acute Valproic Acid Intoxication Successfully Treated with Liver Support Therapy.
- Authors
Ge, Yongchun; Xu, Bin; Zhu, Shuhua; Li, Chuan; He, Qunpeng; Zhu, Tingting; Fan, Rong; Gong, Dehua
- Abstract
Valproic acid ( VPA) is widely used for the treatment of epilepsy. However, its overdose can cause intoxication and could be life-threatening. Due to the lack of specific antidote and poorness of endogenous clearance, extracorporeal treatment for severe intoxication cases is indicated. Here, we report a case of severe intoxication of VPA which was successfully treated with liver support therapy. A previously healthy woman was admitted due to coma and hypotension after intentional ingestion of 20 g of sodium valproate. Her serum concentration of VPA measured on admission was 420.84 mg/L. In addition to standard therapy, she received two sessions of extracorporeal blood purification using a system based on fractionated plasma separation and adsorption mode integrated with continuous veno-venous haemofiltration ( FPSA- CVVH), which is usually used for liver support therapy at our hospital. Her serum concentration of VPA decreased dramatically to 40.18 mg/L and her consciousness recovered completely within 24 hr after admission. Therefore, although haemodialysis has been reported to be effective in the treatment for VPA poisoning, FPSA- CVVH may provide an option for patients who require bedside therapy but have an unstable haemodynamic status or other conditions that result in inability to endure haemodialysis.
- Subjects
DRUG toxicity; BLOOD filtration; ARTIFICIAL blood circulation; HEMODIALYSIS
- Publication
Basic & Clinical Pharmacology & Toxicology, 2017, Vol 121, Issue 4, p368
- ISSN
1742-7835
- Publication type
Article
- DOI
10.1111/bcpt.12807