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- Title
SYNTHESIS, PURIFICATION AND MASS CONFIRMATION OF PHTHALDEHYDE DERIVATIVES OF CONJUGATED AROMATIC SCHIFF BASES WITH AROMATIC AMINES FOR EFFECTIVE ANTIMICROBIAL ACTIVITY.
- Authors
ZAHOOR, A. F.; YOUSAF, M.; AFTAB, K.; ANJUM, A.; KULSOOM, G. A.; PARVEEN, B.; AHMAD, N.; GAFFAR, A.; ANJUM, M. N.
- Abstract
In this study totally 4 aromatic conjugated Schiff bases were prepared in reasonable yield by reacting phthalaldehyde with mono- and di- aromatic amines in either 1:2 molar or equi molar quantities. After purification, the masses of resulting compounds were confirmed using mass spectrometry. Further purity was confirmed using elemental analysis and determining the melting points. All the compounds exhibited sharp melting points being 130, 195, 145, and 135°C for compounds 1, 2, 3 and 4, respectively. The antimicrobial potential of these Schiff bases was evaluated by comparing the results with standard drugs such as rifamipicin (C43H58N4O12), a standard antibacterial drug and fluconazole (C13H12F2N6O), a standard antifungal drug. The results showed that compound C28H20N2 (3) exhibited the better activity against all the tested strains of bacteria, especially 10.25±0.850 and 10.45±0.750 mm for E. coli and B. subtilus as well as fungi, especially 10.55±0.977 and 11±2.150 mm against A. flavous and A. alternate, respectively. Compound C18H12N2 (4) expressed better efficiency against S. aureus being 10.15±0.875 mm and against A. alternate being 10.6±0.675 mm, respectively than other strains. Compound C20H16N2 (1) expressed the least potential against all the strains as compared with other tested compounds. The availability of greater labile π-electrons which increase the lipophilicity of compound 3 as compared with others proved to be the chief factor for the improved antimicrobial potential. Hence Schiff bases with increased conjugations can be designed to prepare the medicinal compounds successfully against resisting pathogens.
- Subjects
SCHIFF base derivatives; AROMATIC amines; ANTI-infective agents; CHEMICAL synthesis; FLUCONAZOLE
- Publication
Oxidation Communications, 2015, Vol 38, Issue 4, p1765
- ISSN
0209-4541
- Publication type
Article