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- Title
The SARS-CoV-2 Antibodies, Their Diagnostic Utility, and Their Potential for Vaccine Development.
- Authors
Hajissa, Khalid; Mussa, Ali; Karobari, Mohmed Isaqali; Abbas, Muhammad Adamu; Ibrahim, Ibrahim Khider; Assiry, Ali A; Iqbal, Azhar; Alhumaid, Saad; Mutair, Abbas Al; Rabaan, Ali A.; Messina, Pietro; Scardina, Giuseppe Alessandro
- Abstract
Antibodies (Abs) are important immune mediators and powerful diagnostic markers in a wide range of infectious diseases. Understanding the humoral immunity or the development of effective antibodies against SARS-CoV-2 is a prerequisite for limiting disease burden in the community and aids in the development of new diagnostic, therapeutic, and vaccination options. Accordingly, the role of antiviral antibodies in the resistance to and diagnosis of SARS-CoV-2 infection was explored. Antibody testing showed the potential in adding important diagnostic value to the routine diagnosis and clinical management of COVID-19. They could also play a critical role in COVID-19 surveillance, allowing for a better understanding of the full scope of the disease. The development of several vaccines and the success of passive immunotherapy suggest that anti-SARS-CoV-2 antibodies have the potential to be used in the treatment and prevention of SARS-CoV-2 infection. In this review, we highlight the role of antibodies in the diagnosis of SARS-CoV-2 infection and provide an update on their protective roles in controlling SARS-CoV-2 infection as well as vaccine development.
- Subjects
VACCINE development; SARS-CoV-2; IMMUNOGLOBULINS; ANTIBODY titer
- Publication
Vaccines, 2022, Vol 10, Issue 8, p1346
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines10081346