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- Title
Hepatic iron accumulation may be associated with insulin resistance in patients with chronic hepatitis C.
- Authors
Sumida, Yoshio; Kanemasa, Kazuyuki; Fukumoto, Kohei; Yoshida, Naohisa; Sakai, Kyoko
- Abstract
Background/Aim: Insulin resistance and hepatic iron overload are frequently demonstrated in hepatitis C virus (HCV)-related liver diseases. We investigated the relationship between insulin resistance and hepatic iron deposition in patients with chronic HCV infection. Methods: Insulin resistance was evaluated using the homeostasis model assessments for insulin resistance (HOMA-IR) in 56 non-diabetic non-obese patients with biopsy proven chronic hepatitis C. The relationship between insulin resistance and serum ferritin levels or the grade of hepatic iron deposition was assessed. Results: The levels of plasma immunoreactive insulin (IRI) and HOMA-IR were significantly correlated with serum ferritin levels and the grade of hepatic iron deposition ( P = 0.003).Although IRI and HOMA-IR increased in parallel with the development of hepatic fibrosis, insulin resistance (HOMA-IR > 2) was observed in 11 (26.2%) of 42 patients even without severe fibrosis (F0–2). Among patients without severe fibrosis, IRI and HOMA-IR were significantly higher in patients with iron deposits than in those without iron deposits. Conclusion: Hepatic iron overload may be associated with insulin resistance in patients with chronic hepatitis C, especially in patients with mild to moderate fibrosis.
- Subjects
INSULIN resistance; HEPATITIS C virus; LIVER diseases; HEPATITIS C; FIBROSIS
- Publication
Hepatology Research, 2007, Vol 37, Issue 11, p932
- ISSN
1386-6346
- Publication type
Article
- DOI
10.1111/j.1872-034X.2007.00152.x