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- Title
Clinical characteristics of cuticular drusen in the Japanese population.
- Authors
Sakurada, Yoichi; Tanaka, Koji; Miki, Akiko; Matsumoto, Hidetaka; Kawamura, Akiyuki; Mukai, Ryo; Akiyama, Hideo; Honda, Shigeru; Mori, Ryusaburo; Iijima, Hiroyuki
- Abstract
Purpose: To investigate the clinical characteristics of eyes with cuticular drusen in Japanese individuals, while paying special attention to large colloid drusen (LCD). Study design: Retrospective case series. Methods: Eyes with cuticular drusen, from patients of 4 medical institutes in Japan, were investigated. Multimodal imaging findings were used to diagnose cuticular drusen. LCD was defined as cuticular drusen > 200 µm. Results: Twenty-four eyes from 12 patients (8 women, 4 men) were diagnosed with cuticular drusen. The mean age of all patients (n = 12) was 60.8 years. The mean age of patients without additional macular pathology (n = 5) was 55.4 years. Of the 7 patients with additional macular pathology, 6 (85.7%) exhibited age-related macular degeneration-associated macular pathology, including drusenoid pigment epithelial detachment (PED) (8 eyes from 4 patients), geographic atrophy (2 eyes from 1 patient), and occult choroidal neovascularization (1 eye). LCD were found in 6 eyes of 3 patients (25%), those with LCD were on average 53.7 ± 8.7 years old and those without 69.9 ± 14.1 years of age (P = 0.064, Mann–Whitney U test). Conclusions: Cuticular drusen were predominantly seen in females, and drusenoid PED was most frequently seen in eyes with additional macular pathology. LCD were seen in 25% of eyes with cuticular drusen.
- Subjects
JAPAN; MANN Whitney U Test; CHOROID diseases
- Publication
Japanese Journal of Ophthalmology, 2019, Vol 63, Issue 6, p448
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-019-00692-5