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- Title
2 型糖尿病患者下肢血管病变与血清25 羟维生素D 及骨密度的相关性.
- Authors
王贺; 阳琰; 张国豪; 王莲地; 刘贝贝; 李琪
- Abstract
Objective To investigate the correlation between lower limb peripheral arterial disease and serum level of 25-hydroxyvitamin D, bone mineral density in patients with type 2 diabetes mellitus (T2DM). Methods A total of 235 T2DM patients were enrolled in this study. All the patients were divided into two groups according to the ankle brachial index ( ABI, measured with Doppler blood flow detector) : PAD group ( ABI <0. 9 group, n = 115) and NPAD group ( ABI5≥ 0. 9, n = 120). Bone mineral density (BMD) of the lumbar spine (LI-4), left femoral neck (Neck), greater trochanter (troch), and Wards triangle (Ward's) was measured using dual energy X-ray absorptiometry (DEXA). Serum level of 25 (OH) D was measured. Clinical data and biochemical indices were collected. Results Serum 25 ( OH)D level was lower in PAD group than that in NPAD group (10. 89 ± 1.48 ng/ml vs 15. 82 ± 2.35 ng/ml, P <0.05 ). BMD of Neck, troch, and Wards in PAD group was lower than that in NPAD group (0.706 ±0. 171 g/cm2 vs 0. 823 ±0. 133 g/cm2, 0. 501 ±0. 111 g/cm2vs 0. 595 ±0. 125 g/cm', and 0. 455 ± 0.121 g/cm2vs 0. 524 ±0.210 g/cm2, respectively, P <0.05). Pearson correlation analysis showed that ABI was negatively correlated with age, duration of diabetes, systolic blood pressure (SBP), total cholesterol (TC), low-density lipoprotein (LDL-C), and glycosylated hemoglobin (HbAlC), but was positively correlated with25(OH)D, BMD of troch, Neck, and Wards, and the differences were statistically significant (PcO. 05). Logistic analysis showed that SBP, HbAlc, TC, 25(OH)D, Neck BMD were risk factors of lower limb peripheral arterial disease in patients with T2DM. Conclusion Patients with T2DM combined with lower limb peripheral arterial disease often have osteopenia or osteoporosis at the same time. Low levels of 25 (OH) D and lower limb BMD may be involved in the development of lower limb peripheral arterial disease in T2DM patients.
- Subjects
ARTERIAL diseases; TYPE 2 diabetes; BONE density; SYSTOLIC blood pressure; LOW density lipoproteins
- Publication
Chinese Journal of Osteoporosis, 2017, Vol 23, Issue 11, p1401
- ISSN
1006-7108
- Publication type
Article
- DOI
10.3969/j.issn.1006-7108.2017.11.001