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- Title
Seasonal variation of 25-hydroxyvitamin D level in patients with senile osteoporosis.
- Authors
JIANG Lihong; WANG Qiujin; ZHOU Ping; ZHU Xiuying; WANG Liping; TAO Tianzun; FAN Ying; MENG Jia
- Abstract
Objective This study aims to analyze the current clinic treatment using vitamin D for osteoporosis and its relationship with season via measuring the 25-hydroxyvitamin D3 [25 (OH) D3] level in senile patients with osteoporosis. Methods Fifty cases of senile osteoporosis were included in this study (in accordance with the WHO diagnostic criteria for osteoporosis, 1994), in which 28 were males with mean age of 75.6 ± 1.5 years, and 22 were females with mean age of 69. 3 ± 2.6 years. Radioimmunoassay was applied to determine the serum 25 (OH) D3 level in summer and winter, respectively. The content of calcium, phosphorus, alkaline phosphatase, and parathyroid hormone were also measured. Results Among all of the patients, the serum 25 (OH) D3 levels in summer were significantly higher than those in winter (males: 42.5% higher, females: 54.6% higher, P < 0.05). The vitamin D deficiency situation was 13.64% of women in summer and 36. 36% in winter, 7. 14% of men in summer and 35.71% in winter, respectively. Significantly high vitamin D deficiency happened in winter comparing with that in summer (P < 0. 05). The serum calcium, phosphorus, alkaline phosphatase, and parathyroid hormone levels were within the normal range in two groups. Conclusion There are different degrees of vitamin D deficiency in elderly patients with osteoporosis in different seasons. The serum 25(OH)D3 levels in winter were lower. It is recommended of scientific and rational application of vitamin D among the elderly. The serum 25(OH)D3 levels should be regularly monitored as routine laboratory test for osteoporosis treatment, which may provide theoretical basis for reasonable clinical application of vitamin D in the treatment of senile osteoporosis.
- Subjects
THERAPEUTIC use of vitamin D; OSTEOPOROSIS treatment; OSTEOPOROSIS; RADIOIMMUNOASSAY; PARATHYROID hormone; VITAMIN D deficiency
- Publication
Chinese Journal of Osteoporosis, 2014, Vol 20, Issue 11, p1357
- ISSN
1006-7108
- Publication type
Article
- DOI
10.3969/j.issn.1006-7108.2014.11.021