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- Title
Effect of general mechanical vibration on abnormal hemorheology status in ovariectomized osteoporotic rats.
- Authors
TAN Xin; WEI Qiushi; CHEN Xianhong; SUN Weishan; SHAO Yu; DENG Weimin
- Abstract
Objective To investigate the effect of general mechanical vibration on hemorheology in ovariectomized osteoporotic rats. Methods Twenty-four 7-month female SD rats were randomly divided into 4 groups: control group, ovariectomized group, general mechanical vibration group, and Fumeijia group. After 8-week treatment, the bone mineral density (BMD) and the bone mineral content (BMC) of the left femur was detected. Hemorheology detection was also performed. Results BMC and BMD in ovariectomized group were significantly lower than those in control group (P < 0. 05). BMD in control group and Fumeijia group was significantly higher than that in ovariectomized group and general mechanical vibration group (P < 0. 05). BMD in general mechanical vibration group was higher than that in ovariectomized group (P < 0. 05). Compared with that in control group, the levels of 200/S, 30/S, 3/S, TK, IR, and EPT in ovariectomized group increased significantly (P<0. 05). The level of 30/s in general mechanical vibration group was lower than that in ovariectomized group (P < 0. 05). Compared with that in control group, no significant difference was observed. Conclusion The hemorheology in ovariectomized rats is abnormal. The general mechanical vibration can improve the abnormal viscosity of 30/s in whole blood, and increase BMD and BMC in variectomized rats.
- Subjects
MECHANICAL vibration research; HEMORHEOLOGY; OVARIECTOMY; OSTEOPOROSIS; BONE density; LABORATORY rats
- Publication
Chinese Journal of Osteoporosis, 2014, Vol 20, Issue 4, p353
- ISSN
1006-7108
- Publication type
Article
- DOI
10.3969/j.issn.1006-7108.2014.04.002