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- Title
Endocrine, molecular and growth performance characteristics associated to the obesity of the Mexican Hairless pig.
- Authors
Camacho-Rea, Carmen; Gutiérrez, Carlos G.; Arechavaleta-Velasco, Miguel E.; Díaz-Cueto, Laura; Arechavaleta-Velasco, Fabián J.; Rodríguez, Roberto Martínez; Lemus-Flores, Clemente; Alonso-Morales, Rogelio A.
- Abstract
To establish the potential of the Mexican hairless pig as an animal model for the study of obesity, a comparative study between the Mexican hairless pigs (MHP) and Landrace-Yorkshire pigs (LYP) was performed. Leptin and insulin serum concentrations were measured and its correlation with backfat thickness was estimated. Feed intake, daily weight gain and backfat thickness was evaluated. Gene expression of leptin, leptin receptor, adiponectin and peroxisoma proliferator activated receptor gamma (PPAR-γ) in adipose tissue were also evaluated. The LYP had a higher weight gain (P<0.05). There were no differences for feed intake measured as a proportion in relation to the body weight between groups (P>0.05). However, the backfat thickness was higher in the MHP (P<0.01). A correlation of 0.73 between leptin concentrations and backfat thickness was found in the MHP (P<0.01) and a correlation of 0.75 in the LYP (P<0.01). However, the insulin concentrations only showed a positive correlation of 0.43 with backfat thickness in the MHP (P<0.05). The MHP showed higher gene expression for adiponectin, leptin and leptin receptor (P<0.05), but no differences were found for the gene expression of PPAR-γ between groups. The Mexican hairless pigs showed a higher capacity for backfat deposition, higher leptin and insulin serum concentrations and higher expression of the genes associated with obesity. These results suggest that Mexican hairless pigs could be a better animal model for the study of obesity than Landrace-Yorkshire pigs.
- Subjects
SWINE physiology; ENDOCRINE genetics; SWINE growth; GENETIC research; LEPTIN; INSULIN; ADIPOSE tissues; OBESITY
- Publication
Técnica Pecuaria en México, 2008, Vol 46, Issue 4, p345
- ISSN
0040-1889
- Publication type
Article