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- Title
Inflammatory and oxidative stress biomarkers induced by silica exposure in crystal craftsmen.
- Authors
Scalia Carneiro, Ana Paula; Algranti, Eduardo; Chérot‐Kornobis, Nathalie; Silva Bezerra, Frank; Tibiriça Bon, Ana Maria; Felicidade Tomaz Braz, Nayara; Soares Souza, Débora Maria; Paula Costa, Guilherme; Bussacos, Marco Antônio; Paula Alves Bezerra, Olívia Maria; Talvani, André
- Abstract
Background: Identification of biomarkers associated with the diagnosis and prognosis of silicosis would be highly advantageous in the clinical setting. The aim of this study is to evaluate inflammatory and oxidative stress biomarkers in subjects exposed to silica. Methods: A cross‐sectional study of crystal craftsmen currently (n = 34) or formerly (n = 35) exposed and a group of nonexposed subjects (n = 12) was performed. Personal respirable dust samples were collected. Plasma inflammatory mediators (bone morphogenetic protein‐ BMP2 and chemokines CXCL16, and CCL5), oxidative stress enzymes (thiobarbituric acid reactive substances [TBARs] and superoxide dismutase [SOD]), and nitrite (NO2−) were analyzed in parallel with nitric oxide in exhaled breath (FeNO). Results: Being currently or formerly exposed to silica was related to increased levels of CXCL16 and TBARs. Currently, exposed subjects showed decreased levels of SOD. Thirty‐seven craftsmen with silicosis (26 formerly and 11 currently exposed) showed higher levels of CXCL16, which was positively associated with the radiological severity of silicosis. Compared with the nonexposed, subjects with silicosis had higher levels of TBARs and those with complicated silicosis had lower levels of SOD. In multivariate analysis, higher levels of CXCL16 were associated with exposure status and radiological severity of silicosis. Smoking was not a confounder. FeNO did not distinguish between the exposure status and the presence of silicosis. Conclusion: CXCL16 emerged as a potential biomarker that could distinguish both silica exposure and silicosis. TBARs were elevated in exposed individuals. However, their clinical applications demand further investigation in follow‐up studies of representative samples.
- Subjects
SILICA; OXIDATIVE stress; BIOMARKERS; INFLAMMATORY mediators; SUPEROXIDE dismutase
- Publication
American Journal of Industrial Medicine, 2020, Vol 63, Issue 4, p337
- ISSN
0271-3586
- Publication type
Article
- DOI
10.1002/ajim.23088