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- Title
Pure red cell aplasia due to antibody against erythropoietin in hemodialysis patients.
- Authors
Rahbar, Maryam; Chitsazian, Zahra; Abdoli, Firoozeh; Taba, Seyed-Masoud Moeini; Akbari, Hosein
- Abstract
Background: Anemia is a common complication of chronic renal failure due to reduce erythropoietin production by kidneys. Anemia treated with recombinant human erythropoietin (rHu-EPO). Pure red cell aplasia (PRCA) due to antibody production against rHu-EPO is a rare but major complication of this drug. Objectives: The aim of this study was to determine the prevalence of PRCA due to antibodies in dialysis patients with resistant anemia who received erythropoietin. Patients and Methods: We studied 128 under maintenance hemodialysis patients more than 3 month in Kashan. In patients with anemia who received erythropoietin with dose requirements based on weight and anemia and without any another cause for anemia, evaluate for PRCA and anti-rHu-EPO antibody level were measured by ELISA. Results: In this research, 75 patients (58.6%) were male and 53 patients (41.4%) were female. The mean age of the patients was 59.05 ± 16.66 years. The result of analysis showed that 55 (43%) patients had anemia with hemoglobin level less than 10 mg/dL. Only 3 patients had PRCA and antibodies against erythropoietin in serum. There were no correlation between age, gender, cause of renal failure, hemodialysis duration, hemoglobin level, rHu-EPO dose and levels of anti-rHu-EPO antibody serum value. Conclusions: The result of this study indicated that administration of rHu-EPO in dialysis patients afflicted to kidney failure may cause PRCA especially through intravenous injection. However, this change is not statistically significant.
- Subjects
PURE red cell aplasia; RECOMBINANT erythropoietin; HEMODIALYSIS patients; THERAPEUTICS
- Publication
Journal of Nephropathology, 2017, Vol 6, Issue 1, p25
- ISSN
2251-8363
- Publication type
Article
- DOI
10.15171/jnp.2017.05