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- Title
Differential effect of griseofulvin on interferon-γ-induced HLA-DR and intercellular adhesion molecule-1 expression of human keratinocytes.
- Authors
Tamaki, K.; Saitoh, A.; Yasaka, N.
- Abstract
Interferon-γ (IFN-γ) induces major histocompatibility complex (MHC) class II antigen and intercellular adhesion molecule-1 (ICAM-1) expression on human epidermal keratinocytes. Griseofulvin, an extensively used antifungal agent, has been used effectively in the treatment of lichen planus, in which keratinocytes express both HLA-DR and ICAM-1 antigens. In this study, we investigated the effect of griscofulvin on IFN-γ-induced MHC class II antigen and ICAM-1 expression of keratinocytes, and demonstrated that griseofulvin decreased IFN-γ-induced HLA-DR but not ICAM-1 expression.
- Subjects
ANTIGENS; IMMUNITY; IMMUNOGLOBULINS; KERATINOCYTES; ANTIFUNGAL agents; CELLS; SKIN diseases; DERMATOLOGY
- Publication
British Journal of Dermatology, 1992, Vol 127, Issue 3, p258
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1992.tb00124.x