We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Anti-inflammatory mechanism of Apolipoprotein A-I.
- Authors
Xia Tao; Ran Tao; Kaiyang Wang; Lidong Wu
- Abstract
Apolipoprotein A-I(ApoA-I) is a member of blood apolipoproteins, it is the main component of High density lipoprotein(HDL). ApoA-I undergoes a series of complex processes from its generation to its composition as spherical HDL. It not only has a cholesterol reversal transport function, but also has a function in modulating the inflammatory response. ApoA-I exerts its anti-inflammatory effects mainly by regulating the functions of immune cells, such as monocytes/macrophages, dendritic cells, neutrophils, and T lymphocytes. It also modulates the function of vascular endothelial cells and adipocytes. Additionally, ApoA-I directly exerts anti-inflammatory effects against pathogenic microorganisms or their products. Intensive research on ApoA-I will hopefully lead to better diagnosis and treatment of inflammatory diseases.
- Subjects
APOLIPOPROTEIN A; HIGH density lipoproteins; VASCULAR endothelial cells; T cells; DENDRITIC cells; ENDOTHELIUM diseases
- Publication
Frontiers in Immunology, 2024, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2024.1417270