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- Title
Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral Yb(OTf)<sub>3</sub>–pybox complex.
- Authors
Karimi, Babak; Jafari, Ehsan; Mansouri, Fariborz; Tavakolian, Mina
- Abstract
Chiral chloro-indeno pybox has served as a new ligand for the Yb(OTf)3-catalyzed asymmetric Friedel–Crafts alkylation reaction of indoles with nitroalkenes. The tunable nature of pybox ligands enables the rational design of catalysts for optimal performance in terms of both activity and stereoselectivity in a Friedel–Crafts-type reaction. Good to excellent yields and enantioselectivities were obtained for a relatively wide range of substrates, including sterically hindered compounds, under optimized reaction conditions.
- Subjects
NITROALKENES; ALKYLATION; INDOLE compounds; FRIEDEL-Crafts reaction; STEREOSELECTIVE reactions; LIGANDS (Biochemistry)
- Publication
Scientific Reports, 2023, Vol 13, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-023-41921-9