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- Title
Transplant associated infections—The role of the gastrointestinal microbiota and potential therapeutic options.
- Authors
Chan, Samuel; Hawley, Carmel M.; Campbell, Katrina L.; Morrison, Mark; Campbell, Scott B.; Isbel, Nicole M.; Francis, Ross S.; Playford, Elliot G.; Johnson, David W.
- Abstract
Infectious complications are common following kidney transplantation and rank in the top five causes of death in patients with allograft function. Over the last 5 years, there has been emerging evidence that changes in the gastrointestinal microbiota following kidney transplantation may play a key role in the pathogenesis of transplant‐associated infections. Different factors have emerged which may disrupt the interaction between the gastrointestinal microbiota and the immune system, which may lead to infective complications in kidney transplant recipients. Over the last 5 years, there has been emerging evidence that changes in the gastrointestinal microbiota following kidney transplantation may play a key role in the pathogenesis of transplant‐associated infections. This review will discuss the structure and function of the gastrointestinal microbiota, the changes that occur in the gastrointestinal microbiota following kidney transplantation and the factors underpinning these changes, how these changes may lead to transplant‐associated infectious complications and potential treatments which may be instituted to mitigate this risk. SUMMARY AT A GLANCE: This review discusses the changes of gut microbiota following kidney transplantation, the factors underpinning these changes, how these changes may lead to transplant associated infectious complications and potential treatment approaches and their limitations.
- Subjects
KIDNEY transplantation; KIDNEY transplant complications; PATHOLOGY; TRANSPLANTATION of organs, tissues, etc.; GUT microbiome
- Publication
Nephrology, 2020, Vol 25, Issue 1, p5
- ISSN
1320-5358
- Publication type
Article
- DOI
10.1111/nep.13670