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- Title
TRAF1 from a Structural Perspective.
- Authors
Jang, Hyunseok; Kim, Subin; Kim, Do Yeon; Han, Ju Hee; Park, Hyun Ho
- Abstract
Tumor necrosis factor receptor-associated factor (TRAF) proteins play pivotal roles in a multitude of cellular signaling pathways, encompassing immune response, cell fate determination, development, and thrombosis. Their involvement in these processes hinges largely on their ability to interact directly with diverse receptors via the TRAF domain. Given the limited binding interface, understanding how specific TRAF domains engage with various receptors and how structurally similar binding interfaces of TRAF family members adapt their distinct binding partners has been the subject of extensive structural investigations over several decades. This review presents an in-depth exploration of the current insights into the structural and molecular diversity exhibited by the TRAF domain and TRAF-binding motifs across a range of receptors, with a specific focus on TRAF1.
- Subjects
CELL determination; TUMOR necrosis factors; CELL communication; CELLULAR signal transduction; IMMUNE response
- Publication
Biomolecules (2218-273X), 2024, Vol 14, Issue 5, p510
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom14050510