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- Title
On Interactions of Sulfamerazine with Cyclodextrins from Coupled Diffusometry and Toxicity Tests.
- Authors
Sofio, Sara P. C.; Caeiro, André; Ribeiro, Ana C. F.; Cabral, Ana M. T. D. P. V.; Valente, Artur J. M.; Canhoto, Jorge; Esteso, Miguel A.
- Abstract
This scientific study employs the Taylor dispersion technique for diffusion measurements to investigate the interaction between sulfamerazine (NaSMR) and macromolecular cyclodextrins (β-CD and HP-β-CD). The results reveal that the presence of β-CD influences the diffusion of the solution component, NaSMR, indicating a counterflow of this drug due to solute interaction. However, diffusion data indicate no inclusion of NaSMR within the sterically hindered HP-β-CD cavity. Additionally, toxicity tests were conducted, including pollen germination (Actinidia deliciosa) and growth curve assays in BY-2 cells. The pollen germination tests demonstrate a reduction in sulfamerazine toxicity, suggesting potential applications for this antimicrobial agent with diminished adverse effects. This comprehensive investigation contributes to a deeper understanding of sulfamerazine–cyclodextrin interactions and their implications for pharmaceutical and biological systems.
- Subjects
TOXICITY testing; DIFFUSION measurements; BIOLOGICAL systems; ANTI-infective agents; POLLEN; CYCLODEXTRINS
- Publication
Biomolecules (2218-273X), 2024, Vol 14, Issue 4, p462
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom14040462