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- Title
Early SARS-CoV-2 Reinfections Involving the Same or Different Genomic Lineages, Spain.
- Authors
Rodríguez-Grande, Cristina; Estévez, Agustín; Palomino-Cabrera, Rosalía; Molero-Salinas, Andrea; Peñas-Utrilla, Daniel; Herranz, Marta; Sanz-Pérez, Amadeo; Alcalá, Luis; Veintimilla, Cristina; Catalán, Pilar; Martínez-Laperche, Carolina; Alonso, Roberto; Muñoz, Patricia; Pérez-Lago, Laura; de Viedma, Darío García
- Abstract
Centers for Disease Control and Prevention guidelines consider SARS-CoV-2 reinfection when sequential COVID-19 episodes occur >90 days apart. However, genomic diversity acquired over recent COVID-19 waves could mean previous infection provides insufficient cross-protection. We used genomic analysis to assess the percentage of early reinfections in a sample of 26 patients with 2 COVID-19 episodes separated by 20-45 days. Among sampled patients, 11 (42%) had reinfections involving different SARS-CoV-2 variants or subvariants. Another 4 cases were probable reinfections; 3 involved different strains from the same lineage or sublineage. Host genomic analysis confirmed the 2 sequential specimens belonged to the same patient. Among all reinfections, 36.4% involved non-Omicron, then Omicron lineages. Early reinfections showed no specific clinical patterns; 45% were among unvaccinated or incompletely vaccinated persons, 27% were among persons <18 years of age, and 64% of patients had no risk factors. Time between sequential positive SARS-CoV-2 PCRs to consider reinfection should be re-evaluated.
- Publication
Emerging Infectious Diseases, 2023, Vol 29, Issue 6, p1154
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid2906.221696