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- Title
Genomic Analysis of Fluoroquinolone- and Tetracycline-Resistant Campylobacter jejuni Sequence Type 6964 in Humans and Poultry, New Zealand, 2014-2016.
- Authors
French, Nigel P.; Ji Zhang; Carter, Glen P.; Midwinter, Anne C.; Biggs, Patrick J.; Dyet, Kristin; Gilpin, Brent J.; Ingle, Danielle J.; Mulqueen, Kerry; Rogers, Lynn E.; Wilkinson, David A.; Greening, Sabrina S.; Muellner, Petra; Fayaz, Ahmed; Williamson, Deborah A.; Zhang, Ji
- Abstract
In 2014, antimicrobial drug-resistant Campylobacter jejuni sequence type 6964 emerged contemporaneously in poultry from 3 supply companies in the North Island of New Zealand and as a major cause of campylobacteriosis in humans in New Zealand. This lineage, not previously identified in New Zealand, was resistant to tetracycline and fluoroquinolones. Genomic analysis revealed divergence into 2 major clades; both clades were associated with human infection, 1 with poultry companies A and B and the other with company C. Accessory genome evolution was associated with a plasmid, phage insertions, and natural transformation. We hypothesize that the tetO gene and a phage were inserted into the chromosome after conjugation, leaving a remnant plasmid that was lost from isolates from company C. The emergence and rapid spread of a resistant clone of C. jejuni in New Zealand, coupled with evolutionary change in the accessory genome, demonstrate the need for ongoing Campylobacter surveillance among poultry and humans.
- Subjects
NORTH Island (N.Z.); CAMPYLOBACTER jejuni; POULTRY; HUMAN beings; TETRACYCLINES; FLUOROQUINOLONES; DRUG resistance in microorganisms; GENOMICS
- Publication
Emerging Infectious Diseases, 2019, Vol 25, Issue 12, p2226
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2512.190267