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- Title
Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein.
- Authors
Béringue, Vincent; Herzog, Laëtitia; Reine, Fabienne; Dur, Annick Le; Casalone, Cristina; Vilotte, Jean-Luc; Laude, Hubert
- Abstract
To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met129 with field isolates. Unlike classical BSE agent, L-type prions appeared to propagate in these mice with no obvious transmission barrier. H-type prions failed to infect the mice.
- Subjects
PRIONS; BOVINE spongiform encephalopathy; PRION diseases in animals; TRANSGENIC mice; PROTEINS; CREUTZFELDT-Jakob disease; DISEASES
- Publication
Emerging Infectious Diseases, 2008, Vol 14, Issue 12, p1898
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid1412.080941