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- Title
Curcumin-Pretreated Adipose-Derived Stem Cells Enhance the Neuroprotective Ability to Repair Rheumatoid Arthritis-Induced Damage in the Rat Brain.
- Authors
Ju, Da-Tong; Tsai, Bruce Chi-Kang; Sitorus, Maria Angelina; Kuo, Wei-Wen; Kuo, Chia-Hua; Chen, Tung-Sheng; Hsieh, Dennis Jine-Yuan; Ho, Tsung-Jung; Huang, Chih-Yang; Wang, Chien-Hao
- Abstract
Neurodegenerative diseases have become increasingly prevalent in the aged population. Rheumatoid arthritis (RA) is an autoimmune disease that causes systemic inflammation, damaging the neurons. However, only a few treatment options can reduce RA-induced neurodegeneration. This study aimed to evaluate whether adipose-derived stem cells (ADSCs) pretreated with curcumin could ameliorate RA-induced neurodegenerative illness in an RA rat model. Wistar rats were randomly classified into the following four groups: control, RA, RA + ADSC (1 × 106 cells per rat), and RA + curcumin-pretreated ADSC (1 × 106 cells per rat). After treatment for two months, the effects were specifically evaluated in the brains collected from the rats. Our results demonstrated that the transplantation of curcumin-pretreated ADSCs substantially reduced inflammation and apoptosis in the cortices of RA rats compared to those of other groups. Thus, the combination of ADSCs and curcumin exerts a synergistic effect in enhancing neuronal protection in RA rats. In the future, this combination therapeutic strategy can potentially be used as a novel treatment method to reduce RA-induced neurodegenerative disorders.
- Subjects
BRAIN injury treatment; ANIMAL experimentation; INFLAMMATION; CURCUMIN; APOPTOSIS; TREATMENT effectiveness; RATS; COMPARATIVE studies; RHEUMATOID arthritis; STEM cells; NEUROPROTECTIVE agents; BRAIN injuries; STATISTICAL sampling; ADIPOSE tissues; DISEASE complications
- Publication
American Journal of Chinese Medicine, 2022, Vol 50, Issue 5, p1299
- ISSN
0192-415X
- Publication type
Article
- DOI
10.1142/S0192415X22500549