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- Title
Thyroid function and cardiovascular disease risk factors in euthyroid adults: a cross-sectional and longitudinal study.
- Authors
Lee, Jane J.; Pedley, Alison; Marqusee, Ellen; Sutherland, Patrice; Hoffmann, Udo; Massaro, Joseph M.; Fox, Caroline S.
- Abstract
Objective and design We explored the cross-sectional and longitudinal associations of thyroid function within the normal range with cardiovascular disease ( CVD) risk factors and adiposity measures. Patients and measurements A total of 3483 (50·4% women) participants for the cross-sectional CVD study and 1630 (41·2% women) participants for the cross-sectional body composition substudy were drawn from the Framingham Third Generation Exam 1; 2912 participants (50·1% women) for the longitudinal CVD study and 713 participants (35·9% women) for the longitudinal body composition substudy were drawn from the Framingham Third Generation Exams 1-2. Thyroid function was assessed by thyrotropin [thyroid-stimulating hormone ( TSH)] and free thyroxine ( fT4) concentrations within the reference range at Exam 1. The associations between thyroid function and CVD risk factors were modelled via multivariable-adjusted regression models. Multivariable adjustment included age, sex, current smoking, postmenopausal status and BMI. Results Cross-sectionally, higher TSH concentration was associated with increased odds of hypertriglyceridaemia [odds ratio ( OR)=1·10], and higher BMI (β = 0·19 kg/m2), total cholesterol (β = 0·05 mmol/l), triglycerides (β = 0·0006 mmol/l) and subcutaneous adipose tissue ( SAT) volume (β = 38·8 cm3) (all P < 0·05). Cross-sectionally, fT4 was inversely associated with metabolic and adiposity-related CVD risk factors, including obesity ( OR = 1·17), hypertriglyceridaemia ( OR = 1·09), BMI (β = 0·42 kg/m2), total cholesterol (β = 0·05 mmol/l), triglycerides (β = 0·0002 mmol/l), visceral adipose tissue ( VAT) volume (β = −20·7 cm3) and attenuation (0·17 HU) and VAT/ SAT ratio (β = −0·01) (all P < 0·05). However, during 6·1 years of follow-up, baseline TSH and fT4 levels were not longitudinally associated with CVD risk factors and adiposity measures. Conclusions Thyroid function within the normal range is cross-sectionally, but not longitudinally, associated with CVD risk factors and adiposity measures.
- Subjects
THYROID gland function tests; CARDIOVASCULAR diseases; OBESITY; THYROTROPIN; ENDOCRINE function tests
- Publication
Clinical Endocrinology, 2016, Vol 85, Issue 6, p932
- ISSN
0300-0664
- Publication type
Article
- DOI
10.1111/cen.13124