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- Title
AN ASSESSMENT OF THE PIEZOELECTRIC COEFFICIENT AND THE THERAPEUTIC POTENTIAL OF IONIC LIQUID (IL) DISSOLVED HARD KERATIN FROM GOAT HORN DISCARDS.
- Authors
Pradeep, D.; Thakran, M.; Bajaj, S. B.; Kumar, B.; Sobha, K.
- Abstract
Hard Keratin (HK) from goat horn discards was dissolved using Ionic Liquid (IL) called Tetrabutylammonium hydroxide (TBAH, 40% aqueous solution), particles of HK were extracted, evaluated for antioxidant potential and in vitro cell viability against A549 and HEK-293 cell lines. Different material characterization techniques viz. PFM, XRD, FESEM/EDAS, FTIR, and TGA were employed to characterize the extracted hard keratin. PFM characterization revealed a piezoelectric coefficient (d33) of about 22.6 pm/V. FTIR analysis confirmed the presence of reactive Amides I, II & III at 1681, 1527, and 1249 cm-1 respectively. XRD spectrum demonstrated the amorphous phase of the material, and the Crystalline Index (C.I.) is 0.38. Characterization by TGA represents high thermal stability of extracted HK with a mass loss of 64.6% at 974.5°C temperature, reflective of the desired thermal stability for different applications. HK particles showed considerable antioxidant activity and inhibition of Human cell lines to an extent of 40.4% at 10 μg concentration for A549 (Lung Carcinoma cells) and 8.38% at 100 μg for HEK-293 (Human embryonic kidney cells).
- Subjects
KERATIN; LUNGS; IONIC liquids; THERMAL stability; AMORPHOUS substances; CELL lines
- Publication
Rasayan Journal of Chemistry, 2022, Vol 15, Issue 4, p2914
- ISSN
0974-1496
- Publication type
Article
- DOI
10.31788/RJC.2022.1546998